Disinfection And Sterilization Equipment Into A New Direction Of Development Of The Industry

We know that the disinfection of materials often due to one or more of the following reasons: the material flow, easy handling, easy to save and storage, reduce shipping costs, access to the desired product quality. In the production process, due to equipment quality, supporting components and basic research and other aspects still need to be further improved, the current routine disinfection and sterilization is still the main form of disinfection and sterilization.

As each has its own sterilization and sterilization advantages and scope of application, so combined disinfection and sterilization will be the future trend of development. Next, Xiao Bian first and everyone together to understand and discuss under the conventional disinfection and sterilization equipment:

Plastic stopper drum sterilization oven: heating element using stainless steel 304 tubular heater, sub-division in the box inside, under the effect of circulating fans, to promote the convection of hot air, the temperature inside the box uniform. Oven using horizontal laminar flow that side of the side of the back to the wind, the role of the fan, the top of the hot air from the side of the high temperature and high efficiency filter into the box. In the efficient filter outlet equipped with air baffle, so that the box air flow evenly. HD-MJX rubber stopper sterilization oven Oven top with the inlet and outlet, and the inlet with a cooling fan, under the strong fan, the 10,000 air through the high efficiency filter into the box, so that items Achieve rapid forced cooling, outlet equipped with high efficiency filters and throttle, exhaust valve can be wet or manual control of PLC programmable controller. Stainless steel mixing drum from a will be placed in which the cleaning materials, start the transmission mechanism, the material in which the natural flip drying, and set a tray, a discharge convenient. Open the oven door interlock device, when one side door open, the other side of the door can not be opened, and the indicator shows the situation open the door can be set to open the door at the specified temperature. Rubber stopper manufacturers and pharmaceutical manufacturers preferred sterilization equipment

On the door sterilization oven: suitable for pharmaceutical, chemical, food, aquaculture industry materials sterilization, insulation, curing, baking, testing and other heat treatment. Commonly used in pharmaceutical manufacturers Vials, ampoules, rubber stopper, aluminum cover, metal and glassware disinfection and sterilization. Open the door for sterilization before and after the oven door way to facilitate the access of materials and conversion of different purification level of the workshop.

In fact, no matter the type of disinfection and sterilization equipment, its development should also pay attention to the comprehensive utilization of energy conservation and energy, such as the use of a variety of joint heating, transplanted heat pumps and heat pipe technology, the development of solar energy disinfection and sterilization machines; In addition, as human beings attach importance to environmental protection, improve the environmental protection measures of disinfection and sterilization machine to reduce the leakage of dust and exhaust gas, etc., will also be in need of further Direction of the research.

For now, compared with developed countries, there is still a gap between the quality and technology of domestic products. Therefore, our country disinfection and sterilization equipment manufacturing enterprises also need to learn from advanced international technology, combined with the actual use of experience, the development of new technologies to achieve our high disinfection and sterilization equipment, economic and joint.

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High-pressure Steam Sterilization

High-pressure medical lab equipment sterilization (autoclaving) to kill all microorganisms, including spores, including, sterilization is the best, the most widely used methods of sterilization. Method is to require sterilization of materials in a pressure cooker (autoclave) inside, does not spill when heated steam, vapor pressure within the autoclave temperature increases rather increased. At 103.4kPa (1.05kg/cm2) vapor pressure, the temperature reached 121.3 ℃, for 15 ~ 20 minutes. Ordinary medium suitable sterile, physiological saline, surgical instruments, containers and glass syringes, dressings and other articles.

A heat sterilization law
Is the most effective method of sterilization. In 103.4kPa (1.05kg/cm2) vapor pressure, the temperature reached 121.3 ℃, maintain 15 ~ 20min, to kill all microorganisms, including spores, including. Autoclave is made in accordance with this principle, commonly used in the general media, saline, surgical dressings and other high temperature, humidity sterilized items.
Autoclaving is restricted by several factors, such as fats and oils mixed with water can therefore not be sterilized with high pressure steam. Plastics will melt under high temperatures, many chemicals, high temperatures will be destroyed, and so on.

Furthermore, the time required for autoclaving depending on the type and volume of the article to be sterilized. Hot steam must ensure that there is sufficient time to penetrate into the article, so the larger the volume of the article, the longer the time required; article more difficult to penetrate into the steam, the longer the time required.

Note the high-pressure medical equipment sterilization law.

First, the sterile package is not too large ( less than 50cm × 30cm × 30cm), should not be too tight, there must be a gap between the parcel, so that the steam can easily penetrate into parcels central convection. Before sterilization, the vent opening of the tank or cartridge is conducive steam circulation. And the exhaust steam can be discharged quickly to keep goods dry. Sterilization is completed, close the vent tank or box to maintain sterility of items.

Second, cloth items should be placed on metal objects, otherwise cold vapor condensed into water droplets, so damp cloth. Hinder the central steam into parcels, seriously affecting the sterilization effect.

Third, the periodic inspection sterilization effect.

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Stainless Steel Portable Pressure Steam Sterilizer Instructions

1, water plus water in the autoclave steam sterilizer to the above heating pipes (about 3 liters), continuous use must be added above the water.

2, seal: would require sterilization of items evenly scattered and orderly placed in sterilized bucket and then sterilized bucket into the sterilizer, and the cover lid, put the hose into the steam sterilization barrel Galteli inside. After the alignment of the upper and lower groove, symmetrical wingnut tightened to seal the requirements (use if the situation continues to leak tighten the nut can be removed).

3, heating: After ohmic heating, take the child on the first release valve deflated vertical position, so that the cold air sterilizer overflow, when steam emitted when the bleed valve then take the child reset. When the pressure reaches the desired range sterilization, sterilization start time is calculated according to a different article.

4, drying: After instruments, dressings, utensils and other disinfection required when dry, can be disinfected after the end of the steam sterilizer release valve to drain. When the gauge is reset to zero for 1-2 minutes. Then open the lid and continue heating 10min to achieve the purpose of drying.

Note:

1, note that the water level before each sterilization to avoid damage to heating pipes empty beaker.

2, different items should be classified sterilization.

3, always check the pressure gauge when the gauge pointer is not reset, the reading should be allowed to cut off the heat, promptly repair or replace the pressure gauge.

4, when the dry heat sterilizer work, the staff do not leave the scene.

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QYResearch：Global Chromatography Syringes Market Research Re

Global Chromatography Syringes market developing stable in last few years, According Global Chromatography Syringes Market Research Report 2017 Published by QYResearch, in 2016 Global production 1.4 M Unit, in past five years average growth is around 3.12%, global revenue of Chromatography Syringes is nearly 40 M USD .

Hamilton Company, SGE, Thermo Scientific, ILS, Agilent and ITO are the key player in this industry. Most player could not sales their product international.
North America is the largest consumption place, with a consumption market share nearly 34% in 2016. Following North America, Europe is the second largest consumption place with the consumption market share of 27%. China is the fast growing market with average growth at 5%.GC Syringes is the most popular product almost half of consumer choice it. Autosampler Syringes is the product with highest growth.

In the next five years global Chromatography Syringes Market will continual growth at 3%, in 2022 the revenue of Chromatography Syringes will reach around 47 M USD.

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Global X-ray Inspection Systems Market Report 2017

X-ray Inspection Systems is one of the most promising methods of non-destructive testing (NDT). The systems are also viewed as important screening tools for quality control and risk management, with their ability to detect contaminants, defects and inconsistencies in products.

According to <Global X-ray Inspection Systems Market Report 2017>published by QYResearch, The global market for X-ray Inspection Systems is expected to reach about 788.27 M USD by 2022 from 583.12 M USD in 2016, registering a Compounded Annual Growth Rate (CAGR) of 5.14% during the analysis period, 2012-2022.

Globally, the X-ray Inspection Systems industry market is low concentrated as the manufacturing technology of X-ray Inspection Systems is relatively matures than some high-tech equipment. And some enterprises, like YXLON International, Nikon Metrology, Nordson, GE Measurement & Control, etc. are well-known for the wonderful performance of their X-ray Inspection Systems and related services. At the same time, Europe, occupied 33.44% production market share in 2016, is remarkable in the global X-ray Inspection Systems industry because of their market share and technology status of X-ray Inspection Systems.

Digital radiography (DR), computed tomography (CT) and X-ray film are the three major technologies used in X-ray Inspection Systems. Digital radiography (DR) is suitable for the 2D products and often used in general industry such as packaging or food & beverage. Computed tomography (CT) can get the 3D image of the products to be tested, it is usually used for foundry industry and auto

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Various Sterilization Introduction

Sterilization by means of a suitable physical or chemical means to kill microorganisms living in the article or method to remove. This law applies to sterile preparation, raw materials, accessories and medical equipment and other items. Sterile refers to goods does not contain any living micro-organisms. However, for any number of steam bottle sterilizer products, both can not guarantee absolute sterility test can not be used to confirm. Physical or chemical means sterilization tests showed: kill microorganisms on the number of rules to follow, therefore, sterile sterilized items after items sterilization standards generally microbial survival probability – sterility assurance level SAL (Sterility Assurance Level) said. Probability of surviving microorganisms terminally sterilized product shall not exceed 10-6. Sterilized products meet the sterility assurance level can be determined by verification. Sterilization and sterility assurance products can not rely on sterility testing of the final product, but on the process used in the production of qualified sterilization process, strict management and good GMP comprehensive quality assurance system. Sterilization process should be determined by considering the nature of the items to be sterilized, effective and economic method of sterilization, the sterilization integrity and stability of the article and other factors.
Validate the sterilization process is a necessary condition of sterility assurance. Sterilization process validated only after the delivery of official use. Verify that include:
⑴ written verification program and the development of assessment criteria.
⑵ confirm sterilization equipment technical information is complete, correct installation , and can be in normal operation ( Installation Qualification ).
⑶ confirm critical control equipment and instrumentation to the normal operation ( OQ ) within the parameters specified.
⑷ using sterilized items or items repeated simulation tests to confirm compliance with the sterilizing effect ( Performance Qualification ) .
⑸ Summary and improve a variety of documents and records, written verification reports. Daily production in response to the operation of sterilization procedures to monitor, identify key parameters ( such as temperature, pressure, time, humidity, gas concentration and irradiation sterilization absorbed dose absorption, etc. ) are within the range defined in the verification.

Sterilization procedures should be periodically re-verified. When changes (including sterilization load and number of items changes ) occur when sterilization procedures, should be re- verified. Characteristics of the product prior to sterilization and sterility assurance products is the extent of contamination and pollution associated bacteria. Therefore, strict monitoring of microbial contamination levels before sterilization and sterilization product contamination tolerance of bacteria, and to take all measures in all aspects of production to reduce pollution and ensure control of microbial contamination within the specified limits. After sterilization, the sterilized items should prevent recontamination . Under no circumstances, should be required to ensure that the product container and sealing system in the period in line with sterile requirements.
Sterilization methods have used methods of sterilization heat sterilization, dry heat sterilization, gas sterilization, radiation sterilization and sterile filtration method. The method may be employed in combination with one or more items to be sterilized in the sterilization according to the characteristics. As long as the product allows, should be chosen as the final sterilization method ( ie, product packaging to packaging containers after sterilization ) sterilization. If the product is not suitable for terminal sterilization method, the choice of filter sterilization method or sterile production process sterility assurance requirements, whenever possible, to deal with non- terminally sterilized products as complementary sterilization ( such as circulating steam sterilization ).

First, heat sterilization
Items will be placed in this Act shall mean the use of high-pressure saturated steam sterilization cabinet, hot water spray and other means to make the microbial cell protein, nucleic acid denaturation and kill microorganisms. The Act sterilization capability for heat sterilization is the most effective and most widely used method of sterilization. Medicines, container, medium, sterile clothing, and other items stopper when the temperature and humidity do not change or damage are available sterilization law . Live steam can not completely kill bacterial spores, and can be used as an auxiliary heat-sterilized instruments sterile products.
Moist heat sterilization conditions usually 121 ℃ × 20min or 116 ℃ × 40min procedure can also be used with other temperature and time parameters. In short, we must ensure that SAL items after sterilization ≤ 10-6. The thermal stability of the article, can be over- kill method, the SAL should be ≤ 10-12. Standard sterilizing tattoo equipment of heat-sensitive products F0 time may be less than 8min, but it should be in the whole production process, the product of strict monitoring of microbial contamination, and to take all measures to prevent pollution and reduce microbial resistant bacteria pollution levels, ensure that sterilized product sterility assurance requirements.
When using moist heat sterilization, should be sterilized items are packed and loaded the appropriate way to ensure the effectiveness and uniformity of sterilization.
When moist heat sterilization process validation, testing should be conducted heat distribution, heat penetration testing and validation testing of biological indicators. To determine the distribution of heat sterilizer load and load when the different chambers and the possible existence of cold spots; under no-load conditions, the temperature difference is recognized when the chamber 121 ℃ points should be ≤ ± 1 ℃; Use temperature probe inserted into the actual items or items within the simulation confirmed sterilizer at different loading, the coldest point of the article standard sterilization time (F0) to reach the set standards; further confirmed when the cold spots at different loading biological indicator sterilized items at a sterility assurance level. Law is commonly used biological indicators Bacillus stearothermophilus spores (Spores of Bacillus stearothermophilus).

Second, the dry heat sterilization
Law refers to items in the dry heat sterilizer, sterilization tunnel and other equipment, the use of dry and hot air to kill the microbes or eliminate pyrogen approach. But not suitable for high-temperature sterilization with moist heat sterilization sterilization items, such as glassware, metal containers, fiber products , solid reagents, liquid paraffin etc Act can be sterilized.
Dry heat sterilization conditions is generally 160 ~ 170 ℃ × 120min above , 170 ~ 180 ℃ × 60min or more, or 250 ℃ × 45min or more , may also have other temperature and time parameters. In short, should ensure that their products after sterilization SAL ≤ 10-6. After the dry heat over the killing of products SAL should ≤ 10-12, this time items generally determined prior to sterilization without microbial contamination. 250 ℃ 45min dry heat sterilization can also be removed by aseptic packaging containers and related equipment in the production of filling pyrogenic substances.
When using dry heat sterilization, should be sterilized items are packed and loaded the appropriate way to ensure the effectiveness and uniformity of sterilization.
Dry heat sterilization and moist heat sterilization validation same test should be carried out heat distribution, heat penetration test, validate biological indicator inactivation of bacterial endotoxin test or validation tests. To confirm the sterilizer temperature distribution in compliance with the standards set, to determine the coldest point, confirm the coldest point standard sterilization time (FH) can reach the set standards and achieve SAL requirements. Commonly used as a biological indicator Bacillus subtilis spores (Spores of Bacillus subtilis). Inactivation of bacterial endotoxin test in addition to verification test is to prove the effectiveness of pyrogenic process. Will generally not be less than 1,000 units of the bacterial toxin to be added to the items of pyrogen, the pyrogen- proof inner process can go down at least three pairs of endotoxin unit. Bacterial endotoxin test to verify inactivation of bacterial endotoxin used generally within Escherichia coli endotoxin (Escherichia coli endoxin). When validated, the general maximum loading mode.

Third, the radiation sterilization
Law refers to the electron beam sterilization product in the γ-ray radiation sources suitable or desirable for the occurrence of electron accelerators ionizing radiation to kill the microorganisms. Law is the most commonly used 60Co-γ ray radiation sterilization. Medical equipment, containers, production aids, from radiation damage of pharmaceutical raw materials and finished products etc. Sterilization Act is available.
Radiation sterilization sterilization method using sterile product which SAL should ≤ 10-6. γ -ray radiation sterilization is mainly controlled by the parameters of the radiation dose ( absorbed dose refers sterilized items ). The dose should be considered sterile goods develop adaptability and the maximum number of possible microbial contamination and the strongest anti- radiation, the dose should be used in advance to verify its effectiveness and safety. The absorbed dose of radiation sterilization used as 25kGy. The final product, bulk drugs, certain medical equipment sterilization should be used whenever possible low radiation dose. Before sterilization, items to be sterilized response quantity of microbial contamination and radiation intensity was measured to evaluate the sterilization process of the sterilized items given sterility assurance level.
When sterilization should be appropriate chemical or physical methods for sterilizing articles absorbed radiation dose monitor the extent to fully confirm the sterilization dose is absorbed in the article required. Such as the use of radiation and sterilization items are together radioactive dosimeters, dosimeter to put the provisions of the site. Dosimeter in the early installation using standard calibration source and regularly re- calibration.
When 60Co-γ ray radiation sterilization validation, verification testing in addition to biological indicator, it should also confirm that the radiation dose distribution of load and loading chamber sterilization, sterilization items absorbed dose and the maximum and minimum absorption dose distribution uniformity, loading patterns sterilization chamber and other items sterilized items. Commonly used as a biological indicator Bacillus pumilus spores (Spores of Bacillus pumilus).

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P3 Laboratory Sterilizers Introduction

P3 Laboratory Sterilizers Introduction

P3 laboratory biosafety level three laboratory. Biological safety laboratory according to the damage degree of different microorganisms and their toxins, can be divided into 4 levels, one level is the lowest, the highest level four. A laboratory is generally applicable to non pathogenic role in healthy adult microorganism; two level suitable for medium potentially harmful microorganisms on people and the environment; three level applies mainly through respiratory pathways that people infected with severe or fatal disease pathogenic microorganisms or their toxins; four level suitable for dangerous height on the human body, spread by aerosol path or route of transmission is unknown, the pathogenic microorganism is no effective vaccine or treatment or its toxin.

The P3 laboratory is the highest laboratory safety protection, requirements for laboratory is also very high, usually require autoclaves, inoculating loop sterilizer, epoxy ethane sterilizer, hydrogen peroxide plasma sterilization etc. Due to the sterilization products requiring high and not every brand can satisfy this requirement, if the construction of the laboratory, especially the international certification P3 laboratory is best to buy imported products, of course, such costs are very expensive, below I will see about for P3 lab products.

Autoclave:

The first is the German Systec products, as the world’s best sterilizer company, Systec is the first to bear the brunt of the double door series, DS is an excellent choice for P3 laboratory, double door in full compliance with the P3 laboratory sterile requirements, but know the price before you are fully prepared oh, 90L sterilizer dealers purchase price 30000 euro, 150L to 40000 euros to 50000 euros, 200L. Germany MBT autoclaves and the United States of America, Terry set can also select the range, the price is slightly lower, but converted into yuan to several hundred thousand dollars.

Dry heat sterilizer — inoculating loop sterilizer

The United States of America KENDALL inoculating loop sterilizer is designed for the P3 laboratory, with professional certification, the price is very high, dealers to buy to 5000 yuan, the market price is 5500, while the ordinary import dry heat sterilizer price as long as 2000 yuan, almost no profit, but regular P3 laboratory is the best choice of the sterilizer.

Ethylene oxide sterilizer

It can be applied to the P3 Laboratory of ethylene oxide sterilizer, only Japan and the United States of America Misaki Sato 3M production, the price is very high, with ethylene oxide sterilizer price to $500000 Misaki Sato 250L double door P3 laboratory, while 3M to more than million, because the price is too high, so the two manufacturers produced little door products, but can according to the customer request custom-made

The P3 laboratory is a stranger that not well-known to the world, a fan of thick door let this little lab isolated from the outside world, mysterious and quiet, the products also have very high demand, product price high is worth, if you are preparing to construct the P3 laboratory to choose sterilization equipment, please find us, we provide the cheapest product safety performance of P3 laboratory highest for you, pack your satisfaction! Days were medical provide first-class products for your lab.

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